The Game Boy Advance has become the modern flagship of sprite-based games. With hardware superior to the Super NES it has proven that sprite-based technology could improve and live side by side with the 3D games of today's consoles. The Game Boy Advance not only has one's typical platformers, but also a huge collection of SNES-style RPGs. It has also become a popular system for old-school gamers due to the increasing amount of games ported from various 8-bit and 16-bit systems of the previous era. Through the use of flash cartridges and emulators the Game Boy Advance can even play NES and PC Engine games, as well as AGI-based Sierra On-Line PC adventure games.

Standout original titles include:

* Mario vs. Donkey Kong
* Advance Wars
* Boktai
* Castlevania: Aria of Sorrow
* Final Fantasy Tactics Advance
* Fire Emblem
* Golden Sun
* The Legend of Zelda: The Minish Cap
* Mario Kart Super Circuit
* Mario & Luigi: Superstar Saga
* Megaman Zero
* Metroid Fusion
* Metroid: Zero Mission
* Mother 3
* Pokémon Ruby / Sapphire
* WarioWare, Inc.: Mega Microgame$